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Staff Research Associate II
Postdoctoral Scholar

Staff Research Associate II

The Drug Discovery Group is seeking a Staff Research Assistant II to join the IND's high-throughput screening (HTS) team, in support of our expanding Drug Discovery programs in neurodegenerative diseases, including Prion diseases like Creutzfeldt-Jakob disease (CJD), Alzheimer's Disease (AD), Frontotemporal Dementia (FTD), and Parkinson's disease (PD).

This position will contribute, as part of the HTS team, to the screening of FDA-approved and foreign approved drugs (FAD) and chemical compounds in diverse chemical libraries to identify "hits" leading to the discovery and development of treatments and cures for a number of neurodegenerative diseases.

The incumbent will have hands-on experience screening of drugs and compounds using cell-, biochemical-, and other screening based assays, and for converting assays to a HTS format. The successful candidate will join a HTS team, which is part of an overall multidisciplinary Drug Discovery research effort whose research interests span many fields of scientific research and report to the Team Leader. The goal of the team is to identify effective therapeutics against neurodegenerative diseases, including prion diseases like CJD, AD, FTD, PD and other neurodegenerative diseases.

This position will be located at our South San Francisco location. At this time, there are no UCSF shuttles offering service to our South San Francisco location. Employees will be responsible for their own transportation.

REQUIRED QUALIFICATIONS, AND SPECIFIC JOB FOCUS, RESPONSIBILITIES, and EXPECTATIONS:

• B.S. in Biology, Cell Biology, Biochemistry, Immunology or related science with at least 4+ years of applied experience in the areas indicated below, or a Master's of Science degree with at least 1-2 years of experience.
• Technical and scientific experience in mammalian cell culture and sterile technique.
• Technical and scientific knowledge and experience with various techniques, including biochemical protein quantification, protein purification, cell and tissue fractionation, Western blots, ELISA, cell fractionation, immunocytochemistry and immunofluorescence
.
• Experience handling, preparing and tracking chemical compounds.
• Technical and scientific knowledge in data analysis and QC.
• Understanding and use of relational database concepts and hands-on experience with data input, querying, report generation, experimental design and analytical skills.
• 90% of the time will be devoted to hands-on lab work, especially bench work, along with appropriate planning, data analysis, documentation and supply management required to complete all aspects the experimental work and will specifically include the following technical and scientific activities:
  • use, maintenance, and updating of laboratory notebooks.
  • HTS using cell based and biochemical assays.
  • mammalian cell culture and sterile technique.
  • basic molecular biology, biochemistry, ELISA, Western blot, pipetting, robotics, and handling of plates.
  • use and basic programming of automation systems.
  • use and troubleshooting of plate readers, light and fluorescence microscopes.
  • use of computers and all appropriate software, along with basic programming skills.
  • metadata preparation, data acquisition, management and analysis.
• Excellent time management skills.
• Excellent oral and written communication skills, organizational and record keeping skills.
• Ability to work as an effective and efficient team member, and to participate in team meetings and planning.
• Enthusiasm, positive outlook, collegiality and scientific curiosity.

This is a full-time position with excellent benefits. Salary is dependent upon experience.

Interested applicants should submit curriculum vitae with a list of publications, a brief statement of research accomplishments and interests and contact information for three to four professional references.

Applicants should submit a cover letter and resume to drugdiscovery@ind.ucsf.edu. Refer to "Drug Discovery SRA" when applying for this position.

UCSF is an equal opportunity employer. Diversity is encouraged. Veterans, minorities and women are encouraged to apply.
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Postdoctoral Scholar

The Prusiner Laboratory is offering postdoctoral positions in the field of prion biology to highly qualified and motivated postgraduates. To be eligible, candidates must have attained a Ph.D. degree in biochemistry, biophysics, cell biology, genetics, molecular biology or neuroscience, have a passion for research and a strong desire to discover the causes and cures for neurodegenerative diseases.

Inquiries may be directed to: ind@ind.ucsf.edu

Refer to “Postdoctoral Schlor” when applying for this position.
The University of California, San Francisco is an equal opportunity employer.
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